Nelociguat

Nelociguat has been in phase II clinical trials by Bayer for the treatment of erectile dysfunction and heart failure. However, no recent development has been reported.

General Information

Update Date:2015-12-22

Drug Name:
Nelociguat
Research Code:
BAY-60-4552; BAY-604552; BAY-98-7081; Bay-987081
Trade Name:
MOA:
Soluble guanylate cyclase (sGC) activator
Indication:
Erectile dysfunction (ED); Heart failure
Status:
Phase II (Pending)
Company:
Bayer (Originator)
Sales:
ATC Code:
Chemical Structure

Update Date:2015-12-22

Molecular Weight 408.39
Formula C19H17FN8O2
CAS No. 625115-52-8 (Nelociguat);
Chemical Name Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
Nelociguat (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
408.39 5 10 5 147 3.533±1.415
*:Calculated by ACD/Labs software V11.02.