OT-551

OT-551 is in phase II clinical trials for the treatment of cataracts and age-related macular degeneration.

This compound was originally discovered by Othera Pharmaceuticals (acquired by Colby Pharmaceuticals in 2012), and co-developed by National Eye Institute (NEI).

General Information

Update Date:2016-04-21

Drug Name:
OT-551
Research Code:
OT-551; CPC-551
Trade Name:
MOA:
NF-κB inhibitor
Indication:
Age-related macular degeneration (AMD); Cataract surgery
Status:
Phase Ⅱ (Active)
Company:
Colby (Originator)
Sales:
ATC Code:
Chemical Structure

Update Date:2015-11-17

Molecular Weight 277.79
Formula C13H23NO3 • HCl
CAS No. 627085-15-8 (OT-551 Hydrochloride);
627085-11-4 (OT-551);
Chemical Name Cyclopropanecarboxylic acid, 1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl ester, hydrochloride (1:1)
OT-551 Hydrochloride (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
241.33 1 4 4 49.8 1.571±0.331
*:Calculated by ACD/Labs software V11.02.