APC-2059

APC-2059 had been in phase II clinical trials for the treatment of inflammatory bowel diseases and ulcerative colitis. However, this study has been discontinued.

The compound was codeveloped by Celera and Bayer.

General Information

Update Date:2016-02-03

Drug Name:
APC-2059
Research Code:
APC-2059; CRA-2059
Trade Name:
MOA:
Tryptase inhibitor
Indication:
Ulcerative colitis; Inflammatory bowel disease
Status:
Phase II (Discontinued)
Company:
Celera (Originator) , Bayer
Sales:
ATC Code:
Chemical Structure

Update Date:2016-02-01

Molecular Weight 664.76
Formula C34H46N12O8
CAS No. 1356458-66-6 (APC-2059);
Chemical Name D-Mannitol, 1,4:3,6-dianhydro-, 2,5-bis[4-[[4-[(aminoiminomethyl)amino]phenyl]methyl]-1-piperazinecarboxylate]
APC-2059 (Free Acid/Base)Parameters:
MW HD HA FRB* PSA* cLogP*
750.80 10 20 10 266 -0.794±1.039
*:Calculated by ACD/Labs software V11.02.